Elafin and cancer
WebDownload scientific diagram Elafin increases ovarian cancer cell proliferation. (a) Kaplan–Meier analysis for OS in OC patients according to the expression of PI3 probe 41469_at (n=1058). (b ... WebNov 5, 2024 · Background: A major cause of mortality in patients receiving hematopoietic stem cell transplantation (HCT) is acute graft-versus-host disease (GVHD), a multiorgan disorder that includes the skin, liver and gastrointestinal tract.We have previously identified elafin, a protease inhibitor overexpressed in inflamed epidermis, as a diagnostic …
Elafin and cancer
Did you know?
WebSep 8, 2014 · The loss of elafin expression during breast cancer progression may promote tumor growth as a consequence of increased NE activity. To address the role of NE in … WebWe measured their serum elafin levels at baseline and followed them until the date of cancer death or until January 2024, the end of this study. Those with high serum elafin levels …
WebJan 6, 2010 · Elafin concentrations also correlated with the eventual maximum grade of GVHD and with nonrelapse mortality. These results show that elafin concentrations may serve as a noninvasive diagnostic test as well as a prognostic marker in determining GVHD grading in the clinic. ... Cancer Center Core grant P30 CA46592, Doris Duke Charitable … WebDec 31, 2014 · Elafin is an endogenous serine protease inhibitor. The majority of breast cancer cell lines lack elafin expression compared to human mammary epithelial cells. In …
WebMay 1, 2008 · Abstract. 5395 Ovarian cancer (OvCa) affects over 25,000 women annually in the US, with a mortality rate greater than 70%. The poor survival is due in part to three quarter of all patients are diagnosed with advance stage disease. When ovarian cancer is diagnosed in its early stage the 5-year survival rate exceeds 90%. Early detection would … WebDec 1, 2006 · Abstract. B140 Ovarian cancer (OvCa) is a leading cause of cancer-related death of women in the United States and Europe. Three-quarters of patients have locally advanced or disseminated disease at the time of diagnosis. Cures are rare at advanced clinical stages, placing emphasis on early detection to reduce mortality. A sensitive and …
WebNovel therapeutic targets are urgently needed to improve ovarian cancer treatment efficacy. Elafin, also known as skin-derived antileukoprotease (SKALP) or peptidase inhibitor 3 (PI3), is encoded by a gene belonging to the whey acidic protein (WAP) family [4-6] and is related to human epididymis protein 4 (HE4), one of the best diagnostic ...
WebOct 1, 2011 · Elafin-based therapy is currently being tested in clinical trials in the context of improving clinical outcomes in patients undergoing coronary artery bypass surgery, esophagectomy for esophageal... new prem footballWebFeb 1, 2006 · For example, the proangiogenic role of WFDC1 6 strongly suggests that this protein, like antileukoproteinase 1 and elafin, 3 also has a role in tissue remodelling and repair—processes that are commonly associated with the inflammatory response, cancer progression, and invasion by tumoral cells. 69 Tumour growth and wound healing are ... intuitive freight glasgowWebJan 15, 2013 · Altered expressions of SLPI and elafin have been identified in several carcinomas, and it appears that these aberrations may play a role in tumor formation, stimulation of metastatic potential,... intuitive functionintuitive fs sutton coldfieldWebNov 10, 2024 · Elafin may protect against human neutrophil elastase-mediated cleavage of receptors such as CD40, CD80, and CD86 on dendritic cells, which are essential for the … intuitive genius superpowerWebJul 19, 2010 · Elafin expression is induced in prostate cancer cells treated with genistein, a protein tyrosine kinase blocker that inhibits cell growth and induces apoptosis, 11 and in … intuitive future forum berlinWebJun 9, 2024 · The relationship between Elafin expression and clinicopathological features was analyzed by immunostaining scores and mRNA data of colorectal cancer patients. … intuitive freight solutions