Dahl salt sensitive rat characteristics

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August undefined, 2024

Webchromosome 13 from the normotensive inbred Brown Norway rat was introgressed into the background of the Dahl/Salt Sensitive rat. Characteristics: Insulin Resistant, … WebThe introduction of inbred models of salt-sensitive hypertension has facilitated understanding blood pressure response to dietary salt. Careful examination of one of these models, the Dahl/Rapp rat, has shown that the L-arginine:nitric acid (NO) pathway is integrally involved in production of hypertension in response to an increase in dietary salt.

Epistatic Genetic Determinants of Blood Pressure and Mortality in …

WebOct 23, 2024 · The pregnant Dahl salt-sensitive (S) rat is an established preclinical model of superimposed spontaneous preeclampsia charac-terized by exacerbated hypertension, increased urinary protein excretion, and increased fetal demise. Because of the underlying WebWe concomitantly assessed genomic regions of rat chromosomes 3 and 7 (RNO3 and. Although genetic determinants protecting against the development of elevated blood pressure (BP) are well investigated, less is known regarding their impact on longevity. We concomitantly assessed genomic regions of rat chromosomes 3 and 7 (RNO3 and dany creation anime adventures

Sex-specific genetic determinants for arterial stiffness in Dahl salt ...

WebJan 1, 2003 · A connection between the vitamin D endocrine system and salt-induced hypertension has been shown for the Dahl salt-sensitive (S) rat, a widely studied genetic model of salt sensitivity (12, 13). High salt intake significantly decreases the plasma 25-OHD concentration of S rats (14– 18). WebThe Dahl salt-sensitive hypertensive rat (Dahl SS) is a well-established rodent model of salt-sensitive hypertension and progressive kidney injury. ... Common among these are albinism, behavioral characteristics, such as docility and willingness to breed in captivity, and certain tumor profiles. Overt metabolic diseases such as obesity (Zucker ... WebDec 2, 2024 · Download Citation Salt-sensitive hypertension: modern pathogenetic mechanisms and prospects The article presents the recent data on the pathogenic links and potential targets for the treatment ... dany customer service

Generation and characteristics of rat models of HFpEF and HFrEF.

Characterization of the Dahl salt-sensitive rat as a rodent …

WebSome studies have shown that sodium-sensitive individuals share several characteristics. They include increased forearm vascular resistance, decreased venous compliance, … WebThe Dahl salt-sensitive (DSS) rat is another model of hypertensive CKD and develops hypertension when fed an HSD (Dahl et al., 1962, 1963). In experiments with this strain, low-salt diet generally involves 0.1%–0.4% NaCl, whereas high salt refers to 4%–8% … The Laboratory Rat, Second Edition features updated information on a … birth decorationWebSep 5, 2014 · The Dahl salt-sensitive rat is a spontaneous model of superimposed preeclampsia Ellen E. Gillis,1 Jan M. Williams,1 Michael R. Garrett,1,2 Jennifer N. Mooney,1 and Jennifer M. Sasser1 1Department of Pharmacology and Toxicology,and 2Department of Medicine University of Mississippi Medical Center, Jackson, Mississippi … dany creations

"WebThe Dahl salt-sensitive rat is a commonly used model of salt-sensitive hypertension. Typical rat chow is 1% salt, and diets of 0.1 to 0.4% are considered low-salt diets. Dahl salt-sensitive rats (DS) exhibit an increase in blood pressure when placed on 1% salt or higher. Many investigators use 2 to 8% salt diets in order to invoke the hypertension. " - Dahl salt sensitive rat characteristics

Dahl salt sensitive rat characteristics

WebJul 31, 2024 · Dahl S rat and SR/Jr for the inbred Dahl R rat. S and R rats independently inbred by Iwai and Heine (38) have been available only in Japan (79). SS/Iwai inbred rats are salt sensitive; however, in contrast to SS/Jr rats, SS/Iwai rats have been reported to remain normotensive on a low-salt diet (36, 38, 78). This could be the result of different ... WebThe Dahl salt-sensitive (DSS) rat is another model of hypertensive CKD and develops hypertension when fed an HSD ( Dahl et al., 1962, 1963 ). In experiments with this …

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WebJan 31, 2011 · The DahlS.Z-Leprfa/Leprfa (DS/obese) rat strain was established from a cross between Dahl salt-sensitive rats and Zucker fatty (fa/fa) rats, the latter of which harbor a missense mutation in the ... WebJun 1, 2024 · The goal of this study was to determine whether SGLT2 inhibition alters blood pressure and kidney function via affecting the renin-angiotensin-aldosterone system (RAAS) and Na + channels/transporters along the nephron in Dahl salt-sensitive rats, a model of salt-induced hypertension. Administration of dapagliflozin (Dapa) at 2 mg/kg/day via ...

WebThe Dahl salt-sensitive (DSS) rat is another model of hypertensive CKD and develops hypertension when fed an HSD ( Dahl et al., 1962, 1963 ). In experiments with this strain, low-salt diet generally involves 0.1%–0.4% NaCl, whereas high salt refers to 4%–8% NaCl diet ( De Miguel et al., 2010; Hayakawa et al., 1997; Rapp and Dene, 1985; Yu ... WebSep 9, 1998 · These data support the alpha1 Na,K-ATPase gene as a susceptibility gene for salt-sensitive hypertension in the Dahl S rat model, and provide the basis for the study of the alpha1 Na,K-ATPase locus in human hypertension. ... Rapp JP, Dene H. Development and characteristics of inbred strains of Dahl salt-sensitive and salt-resistant rats ...

WebDahl salt-resistant (SR) rats are protected against hypertension after high salt or high fructose intake. However, whether these rats are also protected against angiotensin II-mediated hypertension has not been investigated. Dahl salt-sensitive (SS) and SR rats were infused with angiotensin II (10 or 50 ng/kg/min) or vehicle via a mini-osmotic ... WebDahl Salt-sensitive rats 68 Hypertension, eccentric or concen- tric hypertrophy, and systolic and/ or diastolic dysfunction dependen- ing on age-dependent timing of high-salt diet ... mimics most HFpEF characteristics seen in humans, incuding exercise intolerance; well established as a HFpEF model Limitation: no identical genotype in control ...

WebThe Dahl salt-sensitive hypertensive rat (Dahl SS) is a well-established rodent model of salt-sensitive hypertension and progressive kidney injury. ... Common among these are …

WebDec 16, 2024 · Dahl/Salt Sensitive (Dahl/SS) rat is the most frequently used animal model of HFpEF 15. We have previously reported that Dahl/SS rat is a model of CRAS 11 , 16 , … birth defect definition pregnancyWebIn other models where autoregulation is lost, such as the renal ablation model, the Dahl salt-sensitive rat, and the fawn-hooded hypertensive rat, renal injury occurs at much lower BP levels. 30 Similarly, interventions that lead to decreased afferent myogenic tone, such as high protein diet or administration of calcium channel blockers, result ... dany daycare seattleWebThe impact of hypertension on left ventricular (LV) structure, pump function, and heart failure in Dahl salt-sensitive rats is poorly characterized but hypothesized to yield insights into the pathophysiology of heart failure with normal or preserved. The impact of hypertension on left ventricular (LV) structure, pump function, and heart failure ... birth defect defWebDec 12, 2016 · The Dahl salt-sensitive rat is a spontaneous model of superimposed preeclampsia. Am J Physiol Regul Integr Comp Physiol 309: R62–R70, ... Development and characteristics of inbred strains of Dahl salt-sensitive and salt-resistant rats. Hypertension 7: 340–349, 1985. birth defect flipper armsWebThe Dahl rat is used as a model of hypertension that is "sensitive" to dietary salt (sodium chloride, NaCl). When dietary salt is supplemented in the Dahl rat, the arterial blood pressure of the "salt-sensitive" strain (S) becomes much greater than that of the "salt-resistant" strain (R). dan y deri swansea bay health boardWebMay 1, 1996 · Other characteristics of the Brookhaven selectively bred Dahl S rats studied herein are similar to those previously published 13 22 34; their SBP averaged 10 to 20 mm Hg higher than SBP of the Dahl R rat irrespective of dietary salt intake (Fig 1), and the ratio of heart weight to body weight was consistently higher in the Dahl S than R rat fed ... dany crisWebof all genetic loci, thus fixing the characteristics of the strains.37 Dahl/Rapp salt-sensitive rats (SSI Jr) and salt-resistant rats (SIX/Jr) are termed S and R, respectively. On 8.0% NaCl chow, young S rats rapidly and uniformly developed low-renin hypertension.38 In contrast, R rats remained nor- birth defect from virus