WebOct 7, 2024 · After inducing TFE3 overexpression by plasmid or TFE3 downregulation by small interfering RNA (siRNA) transfection, MTT, wound healing, and cell migration and invasion assays were used to verify the effects on invasion, migration, and the levels of autophagy-lysosome system-related proteins such as P62/SQSTM1, LC3, CTSL, and … WebJan 13, 2024 · lysosomes and CTSB. HK-2 ce lls were treated with dif ferent. concen trati on of LPS (1 0 m g/mL, 25 m g/mL, 5 0 m g/mL) for 24 h, 48 h and subjected to the CCK8 assay. The results showed that LPS.
Cathepsin B is a mediator of organelle-specific initiation …
WebNov 28, 2024 · The permeabilization and rupture of lysosomes after stress is a biological process relevant to immunity, neurodegeneration and cancer. ... (CtsB), Cathepsin L (CtsL) or Cathepsin S (CtsS) ... WebAug 13, 2024 · Based on high resolution microscopy images, the majority of galectin-positive leaky lysosomes are in direct contact with the telomeric regions of the chromatin and the surrounding chromatin is decorated by the active form of a lysosomal cysteine protease cathepsin B (CTSB) (Hämälistö et al., 2024; Figure 2). As described in more detail later ... granularity of information
Upconversion nanoparticle-based fluorescence resonance energy …
WebMar 23, 2024 · Thus, we conclude that both Ctsb and Ctsd deficiency caused impaired autophagy in the pancreatic acinar cells, and induced CP in mice. ... Lamp2 is a lysosome-associated membrane protein 7 and ... WebThe paradigm of cancer stem cells (CSCs) defines the existence of cells exhibiting self-renewal and tumor-seeding capacity. These cells have been associated with tumor relapse and are typically resistant to conventional chemotherapeutic agents. Over WebOct 10, 2024 · Glucose metabolism promotes O-GlcNAcylation of the lysosome-encapsulated protease Cathepsin B at serine 210, mediated by lysosome-localized O-GlcNAc transferase (OGT), elevating mature Cathepsin B in macrophages and its secretion in the tumor microenvironment (TME). Loss of OGT in macrophages reduces O … chipped forge 1.16.5