WebApr 12, 2024 · Hematopoiesis is maintained and regulated by a bone marrow-specific microenvironment called a niche. In hematological malignancies, tumor cells induce niche remodeling, and the reconstructed niche is closely linked to disease pathogenesis. Recent studies have suggested that extracellular vesicles (EVs) secreted from tumor cells play … WebABSTRACT. Accumulating evidence implicates various autophagy-related (ATG) proteins in cellular secretion. Recently, we identified a new secretory autophagy pathway in which components of LC3 conjugation machinery specify the incorporation of RNA binding proteins (RBPs) and small non-coding RNAs into extracellular vesicles (EVs), resulting in their …
Extracellular vesicle-mediated remodeling of the bone marrow
WebOct 1, 2024 · 1. Introduction. Extracellular vesicles (EVs), including exosomes, are nanoscale lipid bilayer membrane capsules secreted by cells. They contain proteins and … WebAug 26, 2024 · Extracellular vesicles are a heterogeneous group of cell-derived membranous structures comprising of exosomes, apoptotic bodies, and microvesicles. ... Although EVs vary in their origin, biogenesis, secretion, targeting, and final fate [6 ... Increasing the levels of host miRNAs could block the entry and propagation of the virus. … selling quilts for a living
A live cell reporter of exosome secretion and uptake …
WebJul 18, 2024 · Extracellular vesicles (EVs) are sub-micrometer lipid vesicles secreted from parental cells with their information such as DNA, RNA, and proteins. EVs can deliver … WebABSTRACT. Accumulating evidence implicates various autophagy-related (ATG) proteins in cellular secretion. Recently, we identified a new secretory autophagy pathway in which … WebExtracellular vesicles; exosomes; RNA-binding proteins; autophagy Although autophagy is classically viewed as a lysosomal degradation pathway, increasing evidence implicates ATGs in processes distinct from classical autophagy, such as cellular secretion. Indeed, genetic loss-of-function studies have revealed ATGs are required for the efficient ... selling quickly